Hepatitis C: An In-Depth Guide


Rash or itchy skin (pruritus)

Skin rash is a common side effect of hepatitis C treatment. An itchy skin rash (pruritus) may appear on the feet and hands. Some people may feel itchy all over their bodies.


Dry, itchy skin is a side effect of ribavirin and direct acting antivirals used to treat hepatitis C. Pruritus may also occur with severe liver injury or liver failure.


  • If you must deal with the itch, rub your skin instead of scratching it.
  • Keep your fingernails short so that if you accidentally scratch yourself, you don't risk infection by tearing the skin.
  • Talk to your healthcare provider about antihistamines and anti-itch creams.


Drink lots of water.

Wrap a cold pack in a towel and apply it to the rash.

Take an oatmeal bath.

Use unscented skin moisturizers or body lotions.

Use soap that contains a moisturizer or has high oil content.

Use laundry detergents that are formulated to be mild on the skin.

Wear loose-fitting clothing.

Avoid taking long hot showers or baths.