Canadian Guideline on HIV Pre-Exposure Prophylaxis and Nonoccupational Postexposure Prophylaxis

Key points

• Pre-exposure prophylaxis (PrEP) involving daily tenofovir disoproxil fumarate/emtricitabine 300/200 mg, taken orally, is a highly effective strategy for reducing the risk of HIV acquisition in adults who are at high, ongoing risk of infection.
• In gay, bisexual and other men who have sex with men with frequent exposures, an on-demand regimen may also be considered.
• Nonoccupational postexposure prophylaxis (nPEP) involving 28 days of antiretroviral medications is an effective strategy for reducing the risk of HIV acquisition from a recent (within 72 h) incident of moderate or high-risk exposure to HIV.
• PrEP and nPEP should be part of a combination prevention strategy that includes behavioural interventions, such as condoms and counselling on risk reduction.

• Summary Guideline

• Letter of corrections and clarifications
• Appendix 1: Detailed Guideline
• Appendix 2: Clinical questions addressed by guideline
• Appendix 3: Study selection diagrams
• Appendix 4: Summary of findings tables

   

• Provincial/Territorial Coverage of ARV drugs for HIV prevention across Canada: Post-exposure prophylaxis (PEP) and Pre-exposure prophylaxis (PrEP) – Immunodeficiency Clinic, Toronto General Hospital