Wednesday 29 June, 2016 13.00 EDT
Kaletra is the brand name of a product that contains two anti-HIV drugs called protease inhibitors—lopinavir and ritonavir. The most common side effects associated with the use of Kaletra are diarrhea, feeling weak or tired, nausea and vomiting. Kaletra is available in tablets, capsules and as a liquid.
What is Kaletra?
Kaletra is the brand name of two anti-HIV drugs—lopinavir and ritonavir (Norvir)—that are sold together in one tablet or capsule. These drugs are called protease inhibitors.
How does Kaletra work?
When HIV infects a cell, it takes control of that cell. HIV then forces the cell to make many more copies of the virus. To make these copies, the cell uses proteins called enzymes. When the activity of these enzymes is reduced the production of HIV slows.
Kaletra contains two drugs, lopinavir and ritonavir, both of which belong to a group of drugs called protease inhibitors. These drugs affect an enzyme called protease, which is used by HIV-infected cells to make new viruses. Since lopinavir reduces or inhibits the activity of this protease enzyme (hence the name “protease inhibitor"), this drug causes HIV-infected cells to produce fewer viruses.
The purpose of the small amount of ritonavir inside Kaletra is to boost levels of lopinavir in the blood. Ritonavir also helps keep lopinavir levels high for many hours. This is why Kaletra can be taken once or twice daily.
How do people with HIV use Kaletra?
Kaletra is used in combination with several other anti-HIV drugs from different classes, such as other protease inhibitors, nukes (nucleoside analogues) and non-nukes (non-nucleoside reverse transcriptase inhibitors). Combinations such as this are called antiretroviral therapy, or ART. In order for Kaletra to be effective it must be taken with at least two other anti-HIV drugs. For more information on ART, see CATIE's A Practical Guide to HIV Drug Treatment.
For many people with HIV, the use of ART has increased their CD4+ cell counts and decreased the amount of HIV in their blood (viral load). These beneficial effects help to reduce the risk of developing a life-threatening infection. Neither Kaletra nor any other anti-HIV medication is a cure for HIV. It is therefore important that you do the following:
- see your doctor regularly so that he/she monitors your health
- continue to practice safer sex
Painfully swollen pancreas gland—pancreatitis—is a rare complication that has occurred in users of Kaletra. In some of these cases, pancreatitis has been fatal. Symptoms of pancreatitis can include the following:
- abdominal pain
- blood tests reveal high levels of the enzymes amylase and lipase
If you have these symptoms, contact your doctor right away.
1. General side effects
General side effects that have been reported by some Kaletra users include the following:
- unexpected tiredness
2. Liver enzymes
Because ritonavir is metabolized (processed and broken down) by the liver, blood tests may show increased levels of liver enzymes.
Women may experience heavier menstrual periods when using protease inhibitors. Hemophiliacs who use protease inhibitors may experience increased bleeding. If you are a hemophiliac who uses Kaletra and has this problem, let your doctor know about it.
4. Blood sugar
In some people with HIV who use protease inhibitors, levels of sugar (glucose) in the blood become higher than normal. Prolonged bouts of higher-than-normal blood sugar levels may lead to diabetes. At least one study has found that some HIV-positive women, particularly those who are overweight, may be at increased risk for diabetes when they use protease inhibitors. Regular monitoring of your blood to assess sugar levels and other measurements will help you and your doctor be aware of changes that might suggest problems with your blood sugar. Although the risk of developing diabetes is generally low, symptoms that may be related to diabetes (increased thirst, increased urination, unexplained weight loss, fatigue and dry, itchy skin) should be discussed with your doctor.
5. Lipodystrophy syndrome
The HIV lipodystrophy syndrome is the name given to a range of symptoms that can develop over time when people use ART regimens. Some features of the lipodystrophy syndrome include:
- loss of fat just under the skin (subcutaneous fat) in the face, arms and legs
- bulging veins in the arms and/or legs due to the loss of fat under the skin
- increased waist and belly size
- small lumps of fat in the abdomen
- increased breast size (in women)
Together with these physical changes, lab tests of your blood may detect the following:
- increased levels of fatty substances called triglycerides
- increased levels of LDL-cholesterol, or “bad” cholesterol
- increased levels of sugar (glucose)
- increased levels of the hormone insulin
- decreased sensitivity to insulin (insulin resistance)
- decreased levels of HDL-cholesterol, or “good” cholesterol
The precise causes of the HIV lipodystrophy syndrome are not clear and are difficult to understand because in some people with HIV there may be one or more aspects of the syndrome taking place. For instance, some people may experience fat wasting, others fat gain, and others may experience both fat gain and wasting. What is becoming increasingly clear is that unfavourable changes in the lab readings of glucose, cholesterol and triglycerides over a period of several years increase the risk of diabetes and cardiovascular disease. So far, however, the many benefits of ART are much greater than the increased risk of cardiovascular disease or other side effects.
Maintaining a normal weight, eating a healthy diet, exercising regularly and quitting smoking are all important in helping you to reduce your risk of diabetes, heart disease and other complications. Regular visits to your doctor for checkups and blood tests are a vital part of staying healthy. If necessary, your doctor can prescribe lipid-lowering therapy.
Researchers are studying the lipodystrophy syndrome to try to discover ways of helping people with HIV avoid or reduce this problem. To find out more about options for managing aspects of the lipdystrophy syndrome, see CATIE's A Practical Guide to HIV Drug Side Effects.
Kaletra can cause increased levels of cholesterol and triglycerides in your blood.
The effects of Kaletra on the fetus are not known. The manufacturer notes that this drug should only be used by pregnant women if “the potential benefit justifies the potential risk to the fetus.” If you are pregnant or wish to become pregnant, and are taking Kaletra, talk to your doctor.
Like many drugs, lopinavir and ritonavir are broken down and processed (metabolized) by a group of enzymes in the liver and intestines called P450. Taking Kaletra with another drug that is metabolized by the same enzymes can affect levels of each drug in the blood. As a result, levels of some drugs may increase, causing you to experience side effects or making pre-existing side effects worse. Another possibility is that levels of some drugs may decrease, resulting in little or no benefit from those drugs. If lopinavir or ritonavir levels become too low, HIV can develop resistance to lopinavir and your future treatment options may be reduced.
It is therefore important to always consult your doctor and pharmacist about taking any other medication—prescription or non-prescription—including herbs and supplements, to ensure that they do not interfere with your lopinavir or ritonavir levels and vice versa. If you must take a drug that has the potential to interact with your existing medications, your doctor can do the following:
- adjust your dose of either your anti-HIV drugs or other medications
- prescribe different anti-HIV drugs for you
Drug interaction warning
Below are lists of actual and potential drug interactions. This list is not exhaustive. The manufacturer recommends that the following drugs should not be taken with by Kaletra users:
- heart drugs—flecainide (Tambocor), propafenone (Rythmol)
- antihistamines—astemizole (Hismanal), terfenadine (Seldane)
- ergot drugs—ergonovine, ergotamine (Ergomar)
- gastrointestinal motility agents—cisapride (Prepulsid)
- herbs—St. John’s wort
- anti-psychotics—pimozide (Orap)
- sedatives/sleeping pills—midazolam (Versed), triazolam (Halcion)
- lipid-lowering agents—lovastatin (Mevacor), simvastatin (Zocor). The manufacturer suggests the use of other lipid-lowering agents such as pravastatin (Pravachol) and fluvastatin (Lescol).
- drugs to treat erectile dysfunction—sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra). Taking ritonavir with any of these drugs can lead to dangerous side effects and even death. Talk to your doctor if you have erectile dysfunction about how you might use these drugs safely.
In addition to the drugs listed above, here are some more drugs that interact or have the potential to interact with Kaletra. This list is not exhaustive.
The following drugs can reduce levels of lopinavir in the blood:
- non-nucleoside reverse transcriptase inhibitors—efavirenz (Sustiva), nevirapine (Viramune)
- anti-seizure drugs—carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin)
- corticosteroids—dexamethasone (Decadron)
Kaletra can increase levels of the following drugs:
- antibiotics—clarithromycin (Biaxin), rifabutin (Mycobutin)
- antifungals—ketoconazole (Nizoral), itraconazole (Sporanox)
- antiviral agents—all protease inhibitors and tenofovir (Viread)
- calcium channel blockers—nifedipine (Adalat), felodipine (Plendil, Renedil), nicardipine (Cardene)
- erectile dysfunction—sildenafil (Viagra) and likely other, related drugs such as vardenafil (Levitra) and tadalafil (Cialis)
- immunosuppressive agents—cyclosporine (Neoral), tacrolimus (Prograf), sirolimus (Rapamycin)
Kaletra can decrease levels of the following drugs:
- narcotics—methadone; your dose of methadone may need to be adjusted if you are taking Kaletra
- anti-parasite—atovaquone (Mepron)
- oral contraceptives
Resistance and cross-resistance
Over time, as new copies of HIV are made in the body, the virus can change its structure. These changes are called mutations and can cause HIV to resist the effect of ART. Combining Kaletra with at least two other anti-HIV drugs delays the development of drug resistance.
To reduce the risk of developing drug resistance, all anti-HIV drugs should be taken every day exactly as prescribed and directed. It is important that you take your Kaletra every day because resistant virus can develop if levels of lopinavir or ritonavir in the blood fall too low. This may happen if doses are delayed, skipped or not taken as prescribed. If you find you are having problems taking your medication on a regular basis, as directed, speak to your doctor and nurse about this. They can find ways to help you.
Should HIV in your body become resistant to Kaletra, your doctor, with the help of resistance testing, can help put together a new treatment regimen for you.
Feel free to talk with your doctor about your current and future treatment options.
Kaletra is available in three formulations:
The newest formulation is Kaletra tablets and this comes with several advantages over the older capsule formulation, as follows:
- a lower pill burden
- tablets do not require refrigeration
- tablets may be taken with or without food
- tablets may be associated with fewer side effects
Your doctor, nurse or pharmacist can tell you about the availability of Kaletra tablets in your region.
In HIV/AIDS, changes in the way treatments are used may occur relatively quickly. A drug may be approved at one dose but further clinical trials may suggest more tolerable and effective doses, schedules and combinations of drugs. Results from studies may alter the dose at which doctors prescribe a drug, even though such a dose may not be approved by regulatory agencies. However, it can be dangerous to change the dose of your medications without first discussing this with your doctor. Try to take your doses as scheduled. If you miss a dose, take the next dose as soon as possible and resume your normal medication schedule.
1. New to treatment
For people with HIV who have never before taken anti-HIV medicines, also called treatment-naïve people with HIV, Kaletra may be taken once or twice daily. Your doctor will help you decide which schedule is best for you. For this group, the doses are as follows:
- Tablets: the recommended adult dose is 2 tablets twice daily or 4 tablets once daily, in both cases with or without food.
- Capsules: the recommended adult dose is 3 capsules twice daily or 6 capsules once daily, in both cases with food.
- Liquid: the recommended adult dose is 5 ml twice daily or 10 ml once daily, in both cases with food.
Treatment-experienced people with HIV tend to have HIV that is resistant to some therapies. To maintain high levels of anti-HIV medicines in the blood and reduce the risk of developing drug-resistant HIV, dosing is often more frequent for treatment-experienced people with HIV. For this group, the manufacturer recommends the following dose and schedule:
- Tablets: the recommended adult dose is 2 tablets twice daily with or without food.
- Capsules: the recommended adult dose is 3 capsules twice daily with food.
- Liquid: the recommended adult dose is 5 mL taken twice daily with food.
If you miss a dose of Kaletra, Abbott recommends that you take a dose as soon as possible and then return to your normal schedule. You should not take a double dose to make up for the missed dose. If you keep forgetting to take Kaletra, talk to your doctor about this problem.
Doctors prescribing Kaletra to adult PHAs who are also taking nevirapine or efavirenz should consider increasing the dose of Kaletra since these drugs can reduce levels of lopinavir in the blood.
In children between the ages of six months and 12 years, the dose of Kaletra is adjusted depending on the weight of the child.
Kaletra is licensed in Canada for the treatment of HIV infection in adults and children over the age of six months, in combination with other anti-HIV drugs. Kaletra is available in tablet, capsule and liquid form. Your doctor can tell you more about the availability of Kaletra in your region.
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Author(s): Hosein SR