Hepatitis C: An In-Depth Guide

Chronic hepatitis C treatment combinations

The following drug combinations are approved by Health Canada for people with hepatitis C.

Click on the drug name to find out more information about the drug.

Genotype 1 Treatment Combinations

asunaprevir (Sunvepra) + daclatasvir (Daklinza)

daclatasvir (Daklinza) + sofosbuvir (Sovaldi) with or without ribavirin

Epclusa (sofosbuvir + velpatasvir)

Harvoni (sofosbuvir + ledipasvir)

Holkira Pak (dasabuvir + paritaprevir/ritonavir + ombitasvir) with or without ribavirin

Maviret (glecaprevir + pibrentasvir)

sofosbuvir (Sovaldi)  + simeprevir (Galexos)

Vosevi (sofosbuvir + velpatasvir + voxilaprevir)

Zepatier (elbasvir + grazoprevir) with or without ribavirin

Genotype 2 Treatment Combinations

daclatasvir (Daklinza) + sofosbuvir (Sovaldi) with or without ribavirin

Epclusa (sofosbuvir + velpatasvir)

Maviret (glecaprevir + pibrentasvir)

sofosbuvir (Sovaldi) + ribavirin

Vosevi (sofosbuvir + velpatasvir + voxilaprevir)

Genotype 3 Treatment Combinations

daclatasvir (Daklinza) + sofosbuvir (Sovaldi) with or without ribavirin

Epclusa (sofosbuvir + velpatasvir)

Maviret (glecaprevir + pibrentasvir)

sofosbuvir (Sovaldi) + ribavirin

Vosevi (sofosbuvir + velpatasvir + voxilaprevir)

Zepatier (elbasvir + grazoprevir) + sofosbuvir (Sovaldi)

Genotype 4 Treatment Combinations

Epclusa (sofosbuvir + velpatasvir)

Maviret (glecaprevir + pibrentasvir)

Technivie (paritaprevir/ritonavir + ombitasvir) + ribavirin

Vosevi (sofosbuvir + velpatasvir + voxilaprevir)

Zepatier (elbasvir + grazoprevir) with or without ribavirin

Genotype 5 and 6 Treatment Combination

Epclusa (sofosbuvir + velpatasvir)

Maviret (glecaprevir + pibrentasvir)

Vosevi (sofosbuvir + velpatasvir + voxilaprevir)

Note: peg-interferon, telaprevir and boceprevir have been discontinued in Canada.

Other combinations

Some doctors may prescribe combinations of medications that have been approved by Health Canada individually but not together. For example, simeprevir and sofosbuvir are two drugs that are approved for use with peg-interferon and/or ribavirin but not in combination with each other. Some doctors have prescribed these two drugs together. This is sometimes called “off-label” prescribing.

Hep C drugs in development

There are more hepatitis C drugs that are being tested in clinical trials. If and when these drugs are approved by Health Canada they will be added to this article. For more information on Hep C drugs that are in development, subscribe to CATIE’s biweekly e-newsletter HepCinfo Update.

Accessing new medications through clinical trials

Some people in Canada are able to access medications that are still in development by participating in a clinical trial. For more information on clinical trials, see Clinical Trials: What you need to know.