Hepatitis C: An In-Depth Guide

Tingling or burning sensation (parasthesia or peripheral neuropathy)

Sensations of tingling, pins and needles, sharp pain or cramps, burning and numbness may be caused by conditions known as paresthesia and peripheral neuropathy. Usually, the pain is felt in the toes, feet and legs, although sometimes it is in the hands and arms. These sensations are often worse at night.


The exact cause of hepatitis C-related peripheral neuropathy is not known, although possible explanations include hepatitis C infection of the nerves or a swelling process in the nerves triggered by a hepatitis C-related immune disorder.


  • Your doctor may try a number of measures to treat the symptoms, including topical creams, pain killers, antidepressants and non-steroidal anti-inflammatory drugs.


You can try the following tips to help soothe the pain and relieve the pressure on your feet or hands.

Limit your walking distances and the length of time you spend standing.

Wear loose-fitting socks and shoes.

Keep heavy bed covers off painful areas and use a small pillow to raise your feet or hands off the mattress while sleeping.

Regularly soak your feet or hands in ice water.

Exercise regularly to try to improve circulation to the nerves.