Hepatitis C drugs approved in Canada for adults

Treatments for all genotypes (1, 2, 3, 4, 5, 6)

Brand name (generic name)

Image

Dosage schedule

Food requirements

Weeks of treatment

Epclusa
(velpatasvir + sofosbuvir)

One tablet once daily

 

12

with or without ribavirin*

Harvoni
(ledipasvir + sofosbuvir)

One tablet once daily

 

8, 12 or 24

with or without ribavirin*

Maviret
(glecaprevir + pibrentasvir)

Three tablets once daily

Take with food

8, 12 or 16

Vosevi
(sofosbuvir + velpatasvir
+ voxilaprevir)

One tablet once daily

Take with food

12

 

Treatments for genotype 1

Brand name (generic name)

Image

Dosage schedule

Food requirements

Weeks of treatment

Daklinza
(daclatasvir)
+
Sovaldi (sofosbuvir)

One tablet once daily

 

12

One tablet once daily

with or without ribavirin*

Holkira Pak
(ombitasvir + paritaprevir + ritonavir)
+
dasabuvir

Two tablets once daily

Take with food

12 or 24

One tablet twice daily
with or without ribavirin*

Zepatier
(elbasvir + grazoprevir)

One tablet once daily

 

8, 12 or 16

with or without ribavirin*

 

Treatments for genotype 2

Brand name (generic name)

Image

Dosage schedule

Food requirements

Weeks of treatment

Daklinza
(daclatasvir)
+
Sovaldi
(sofosbuvir)

One tablet once daily

 

12

One tablet once daily
with or without ribavirin*

Sovaldi
(sofosbuvir)
+
Ribavirin*

One tablet once daily

 

12

 

Treatments for genotype 3

Brand name (generic name)

Image

Dosage schedule

Food requirements

Weeks of treatment

Daklinza
(daclatasvir)
+
Sovaldi
(sofosbuvir)

One tablet once daily

 

12

One tablet once daily
with or without ribavirin*

Sovaldi
(sofosbuvir)
+
Ribavirin*

One tablet once daily

 

24

Zepatier
(elbasvir + grazoprevir)
+
Sovaldi
(sofosbuvir)

One tablet once daily

 

12

One tablet once daily

 

Treatments for genotype 4

Brand name (generic name)

Image

Dosage schedule

Food requirements

Weeks of treatment

Technivie
(ombitasvir + paritaprevir
+ ritonavir)
+
Ribavirin*

Two tablets once daily

Take with food

12

Zepatier
(elbasvir + grazoprevir)

One tablet once daily

 

12 or 16

with or without ribavirin*

 

*ribavirin as a possible treatment addition

Ibavyr
(ribavirin)
400mg/600mg

Image not available

800 to 1,200 mg/day depending on body weight, twice daily

Take with food

Based on other medications in regimen

Moderiba
(ribavirin)
200mg/400mg/600mg

800 to 1,200 mg/day depending on body weight, twice daily

Take with food

Based on other medications in regimen

 

NOTE

This chart lists common daily dosing schedules. People should always follow the dosing schedule prescribed by their doctor.

Acknowledgements

Funding provided in part by AbbVie Corporation, Gilead Sciences Canada, Inc. and Merck & Co., Inc. Epclusa®,Harvoni®, Sovaldi®, and Vosevi are trademarks of Gilead Sciences, Inc., or its related companies. Images of Epclusa, Harvoni, Sovaldi and Vosevi, copyright Gilead Sciences, Inc., or its related companies. Used with permission. TechnivieTM, MaviretTM and ModeribaTM are trademarks of AbbVie Corporation. Images of Technivie, dasabuvir, Maviret and Moderiba, copyright AbbVie Corporation. Used with permission. Daklinza® is a registered trademark of Bristol-Myers Squibb. Image of Daklinza, copyright Bristol-Myers Squibb Canada. Used with permission. Zepatier® is a registered trademark of Merck & Co, Inc. Image of Zepatier, copyright Merck & Co., Inc. Used with permission.

Disclaimer

Information provided by CATIE is not medical advice. Decisions about medical treatments should always be made in consultation with a medical practitioner knowledgeable about HIV and hepatitis C. CATIE endeavours to provide the most up-to-date and accurate information at the time of publication. However, information changes and users are encouraged to ensure they have the most current information. Any opinions expressed herein may not reflect the opinions of CATIE, its partners or funders.