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CATIE-News: Bite-sized HIV/AIDS news bulletins

Changes in sexual behaviour and HIV risk


The widespread availability of highly active antiviral therapy (HAART) in high-income countries has had a profound impact—deaths from AIDS-related infections are uncommon, at least among people who are engaged in their care and treatment. By suppressing HIV levels, HAART increases CD4+ cell counts and allows the immune system to begin repairing itself. The partial rebuilding of the immune system that occurs because of HAART generally results in renewed energy and, in some cases, the possibility of a return to work or volunteer activities. What’s more, researchers expect that HIV-positive people who are engaged in their care and treatment and who have minimal co-existing health conditions can live near-normal life spans, at least in high-income countries with social-welfare systems.

While HAART has had a profound impact on the health and lives of HIV-positive people, it may have had an inadvertent impact on HIV-negative people, as researchers have found these trends occurring in high-income countries:

  • AIDS is now perceived as a less serious illness than it was before the availability of HAART.
  • Some HIV-negative men believe that their personal risk of getting HIV has now been reduced.
  • Increased and sustained outbreaks of sexually transmitted infections among gay and bisexual men are occurring.
  • Among these men, there has been an increase in unprotected anal intercourse.

An international team of researchers recently found that while HIV infections decreased between 1996 and 2000, they began to increase in 2001 and after in Australia, Canada, France, Germany, the Netherlands, the United Kingdom and the United States.

As there is no cure or effective vaccine for HIV in the short term, the use of condoms remains a vital part of HIV prevention for sexually active people.

Serosorting

In theory, another way to possibly reduce the risk of exposure to HIV is for people to serosort—have sex with other people of the same HIV status.

For HIV-positive people, having sex only with other HIV-positive people may remove the burden of worry about infecting someone else. For HIV-negative people, serosorting may reduce the worry about getting HIV.

In reality, serosorting carries risks, particularly when condoms are not used for intercourse:

  • For HIV-positive people, unprotected anal intercourse can transmit germs such as hepatitis-causing viruses (hepatitis B and hepatitis C viruses), LGV (Lymphogranuloma venereum), syphilis and HPV (human papillomavirus), among others. It can also allow for the transmission of new, perhaps drug-resistant strains of HIV. In the setting of HIV co-infection, hepatitis B and C viruses can cause accelerated liver damage and hepatitis recovery rates are generally lower than in HIV-negative people.
  • For HIV-negative people, unprotected intercourse also carries the risk of transmitting many of the same germs and also HIV. What’s more, HIV antibody testing may provide a false sense of security among people who regularly engage in unprotected intercourse. This is because the immune system takes several weeks to produce antibodies after infection. Testing done during this period may not find any antibodies, even though infection has taken place.

Serosorting—study casts light on risks

Researchers in Seattle conducted a study with gay and bisexual men between 2001 and 2007. They found that serosorting increased over time. Troublingly, they also found that during serosorting some men had unprotected anal intercourse. Although serosorting reduced the men’s risk for getting HIV, their risk for getting this infection was higher than if condoms had been used. What’s more, the study team noted that “from both a personal and public health perspective, the limits of serosorting seem to be profound.” Perhaps they reached this conclusion because serosorting only conferred partial protection from becoming HIV positive. They also found that 32% of all men who were newly diagnosed with HIV reported that unprotected anal intercourse with “a partner they believed to be HIV negative was their most risky sexual behaviour.”

The study team was concerned that serosorting without condoms was such a risky behaviour for HIV negative men. Their findings need to be confirmed by other research teams. The Seattle researchers stated: “We did not routinely collect data on how [participants] knew a partner’s HIV status and some infections attributed to serosorting failure may reflect [participants’] assumptions about partners’ HIV status rather than inaccurate explicit discussions between men before sex.”

This type of serosorting—based on assumptions or guesses—has been coined “seroguessing” by Australian researchers and is the focus of our next CATIE News story.

—Sean R. Hosein

REFERENCES:

  1. Lohse N, Hansen AB, Gerstoft J, et al. Improved survival in HIV-infected persons: consequences and perspectives. Journal of Antimicrobial Chemotherapy. 2007 Sep;60(3):461-3.
  2. Butler D. Jury still out on HIV vaccine results. Nature. 2009 Oct 29;461(7268):1187.
  3. Cohen J. Beyond Thailand: Making sense of a qualified AIDS Vaccine “success.” Science. 2009 October 30; 326(5953):652-3.
  4. Kippax S and Race K. Sustaining safe practice: twenty years on. Social Science and Medicine. 2003 Jul;57(1):1-12.
  5. Pilcher CD, Fiscus SA, Nguyen TQ, et al. Detection of acute infections during HIV testing in North Carolina. New England Journal of Medicine. 2005 May 5;352(18):1873-83.
  6. Sullivan PS, Hamouda O, Delpech V, et al. Reemergence of the HIV epidemic among men who have sex with men in North America, Western Europe and Australia, 1996-2005. Annals of Epidemiology. 2009 Jun;19(6):423-31.
  7. Golden MR, Stekler J, Hughes JP, et al. HIV serosorting in men who have sex with men: is it safe? Journal of Acquired Immune Deficiency Syndromes. 2008 Oct 1;49(2):212-8.

Created on: 11/10/2009

 

Decisions about particular medical treatments should always be made in consultation with a qualified medical practitioner who is knowledgeable about HIV-related illness and the treatments in question. MORE